Table of Contents
September 25, 2003
Volume 46, Issue 20
Pages 4215-4364
About the Cover: Connolly surface map of the X-ray structure of the α-thrombin-cyclopentenedicarboxylic acid derivative complex (yellow) at 1.9 Å resolution superimposed on the X-ray structure of the α-thrombin-PPACK complex (magenta) (Thorstensson, F.; et al. J. Med. Chem. 2003, 46, 1165-1179).
Award Address
Peptide Science: Exploring the Use of Chemical Principles and Interdisciplinary Collaboration for Understanding Life Processes
Victor J. Hruby
pp 4215–4231Publication Date (Web): September 04, 2003 (Perspective)
DOI: 10.1021/jm0303103
Hi-Res PDF Letters
Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor
Gang Liu, Zhili Xin, Zhonghua Pei, Philip J. Hajduk, Cele Abad-Zapatero, Charles W. Hutchins, Hongyu Zhao, Thomas H. Lubben, Stephen J. Ballaron, Deanna L. Haasch, Wiweka Kaszubska, Cristina M. Rondinone, James M. Trevillyan, and Michael R. Jirousek
pp 4232–4235Publication Date (Web): September 03, 2003 (Letter)
DOI: 10.1021/jm034122o
Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions
Tao Wang, Zhongxing Zhang, Owen B. Wallace, Milind Deshpande, Haiquan Fang, Zheng Yang, Lisa M. Zadjura, Donald L. Tweedie, Stella Huang, Fang Zhao, Sunanda Ranadive, Brett S. Robinson, Yi-Fei Gong, Keith Ricarrdi, Timothy P. Spicer, Carol Deminie, Ronald Rose, Hwei-Gene Heidi Wang, Wade S. Blair, Pei-Yong Shi, Pin-fang Lin, Richard J. Colonno, and Nicholas A. Meanwell
pp 4236–4239Publication Date (Web): August 30, 2003 (Letter)
DOI: 10.1021/jm034082o
Oxidosqualene Cyclase Inhibitors as Antimicrobial Agents
Jerald C. Hinshaw, Dae-Yeon Suh, Philippe Garnier, Frederick S. Buckner, Richard T. Eastman, Seiichi P. T. Matsuda, Bridget M. Joubert, Isabelle Coppens, Keith A. Joiner, Salim Merali, Theodore E. Nash, and Glenn D. Prestwich
pp 4240–4243Publication Date (Web): August 29, 2003 (Letter)
DOI: 10.1021/jm034126t
Articles
Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies toward the Development of Artemisinin-Based Drugs against Leishmaniasis and Malaria
Mitchell A. Avery, Kannoth M. Muraleedharan, Prashant V. Desai, Achintya K. Bandyopadhyaya, Marise M. Furtado, and Babu L. Tekwani
pp 4244–4258Publication Date (Web): August 21, 2003 (Article)
DOI: 10.1021/jm030181q
Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins
Shinichi Kitada, Marilisa Leone, Sina Sareth, Dayong Zhai, John C. Reed, and Maurizio Pellecchia
pp 4259–4264Publication Date (Web): August 22, 2003 (Article)
DOI: 10.1021/jm030190z
A Specific Mechanism of Nonspecific Inhibition
Susan L. McGovern, Brian T. Helfand, Brian Feng, and Brian K. Shoichet
pp 4265–4272Publication Date (Web): August 22, 2003 (Article)
DOI: 10.1021/jm030266r
Synthesis and Biological Characterization of 1-Methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole Derivatives as Muscarinic Agonists for the Treatment of Neurological Disorders
Yang Cao, Minjia Zhang, Cindy Wu, Selina Lee, Mary Elizabeth Wroblewski, Trisha Whipple, Peter I. Nagy, Krisztina Takács-Novák, Attila Balázs, Szilárd Tőrös, and William S. Messer, Jr.
pp 4273–4286Publication Date (Web): August 30, 2003 (Article)
DOI: 10.1021/jm0301235
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists. Influence of the N5 Substituent on the Affinity at the Human A3 and A2B Adenosine Receptor Subtypes: A Molecular Modeling Investigation
Giorgia Pastorin, Tatiana Da Ros, Giampiero Spalluto, Francesca Deflorian, Stefano Moro, Barbara Cacciari, Pier Giovanni Baraldi, Stefania Gessi, Katia Varani, and Pier Andrea Borea
pp 4287–4296Publication Date (Web): August 30, 2003 (Article)
DOI: 10.1021/jm030852k
Synthesis and Crystal Structures of Substituted Benzenes and Benzoquinones as Tissue Factor VIIa Inhibitors
John J. Parlow, Anna M. Stevens, Roderick A. Stegeman, William C. Stallings, Ravi G. Kurumbail, and Michael S. South
pp 4297–4312Publication Date (Web): September 06, 2003 (Article)
DOI: 10.1021/jm030233b
The Combi-Targeting Concept: Chemical Dissection of the Dual Targeting Properties of a Series of “Combi-Triazenes”
Zakaria Rachid, Fouad Brahimi, Athanasia Katsoulas, Nicole Teoh, and Bertrand J. Jean-Claude
pp 4313–4321Publication Date (Web): September 03, 2003 (Article)
DOI: 10.1021/jm030142e
SAR Analysis of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol Inhibition of Poly(ADP-ribose) Glycohydrolase
David W. Koh, Donna L. Coyle, Nimish Mehta, Sushma Ramsinghani, Hyuntae Kim, James T. Slama, and Myron K. Jacobson
pp 4322–4332Publication Date (Web): August 29, 2003 (Article)
DOI: 10.1021/jm020541u
Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses: Design, Synthesis, and Biological Evaluation
Chafiq Hamdouchi, Concha Sanchez-Martinez, Joseph Gruber, Miriam del Prado, Javier Lopez, Almudena Rubio, and Beverly A. Heinz
pp 4333–4341Publication Date (Web): August 21, 2003 (Article)
DOI: 10.1021/jm020583i
Structures and Cytotoxic Properties of Trichoverroids and Their Macrolide Analogues Produced by Saltwater Culture of Myrothecium verrucaria
Taro Amagata, Christopher Rath, Jérôme F. Rigot, Nick Tarlov, Karen Tenney, Frederick A. Valeriote, and Phillip Crews
pp 4342–4350Publication Date (Web): August 23, 2003 (Article)
DOI: 10.1021/jm030090t
Metabolites of Febrifugine and Its Synthetic Analogue by Mouse Liver S9 and Their Antimalarial Activity against Plasmodium Malaria Parasite
Shingo Hirai, Haruhisa Kikuchi, Hye-Sook Kim, Khurshida Begum, Yusuke Wataya, Hidehisa Tasaka, Yuriko Miyazawa, Keisuke Yamamoto, and Yoshiteru Oshima
pp 4351–4359Publication Date (Web): August 29, 2003 (Article)
DOI: 10.1021/jm0302086
Brief Articles
Informative Library Design as an Efficient Strategy to Identify and Optimize Leads: Application to Cyclin-Dependent Kinase 2 Antagonists
Erin K. Bradley, Jennifer L. Miller, Eddine Saiah, and Peter D. J. Grootenhuis
pp 4360–4364Publication Date (Web): August 30, 2003 (Brief Article)
DOI: 10.1021/jm020472j